import hashlib
import xlrd
import xlwt

# md5加密函数
def md5(arg):
    str_hash = hashlib.md5()
    str_hash.update(bytes(arg, encoding="utf-8"))
    return str_hash.hexdigest()


# 用xlrd模块读取表格，打开excel表
ExcelFile = xlrd.open_workbook(r"d:\1.xlsx")
sheet = ExcelFile.sheet_by_name("Sheet1")

# 用xlwt模块保存，创建表
writework = xlwt.Workbook()
writesheet = writework.add_sheet("shouji_number", cell_overwrite_ok=True)

# 循环要md5加密的列，
shouji_num = sheet.col_values(4)

i = 0
for line in shouji_num:
    str_sj_num = str(line)
    writesheet.write(i, 9, md5(str_sj_num))  # 加密指定列的数据
    i += 1

# 保存
writework.save("1.xls")