https://sourceforge.net/projects/pywin32/files/pywin32/

# _*_coding:utf-8 _*_
#@Time     :2019/1/26 09:15
#@Author   :聪明的牛 
#@FileName :modifyFileTimeModule.py
#@Compile  :Python 2.7.15
from win32file import CreateFile, SetFileTime, GetFileTime, CloseHandle 
from win32file import GENERIC_READ, GENERIC_WRITE, OPEN_EXISTING
from pywintypes import Time
import time,sys,os

def changeTime(path, filename):
    pathname = os.path.join(path, filename)
    print(pathname);

    cTime = "2019-01-25 00:00:00"    
    aTime = "2019-01-25 00:30:00"
    mTime = "2019-01-25 00:10:00"
    # specify time format
    format = "%Y-%m-%d %H:%M:%S"
    offset = 0 # in seconds

    # create struct_time object
    cTime_t = time.localtime(time.mktime(time.strptime(cTime,format))+offset)    
    aTime_t = time.localtime(time.mktime(time.strptime(aTime,format))+offset)
    mTime_t = time.localtime(time.mktime(time.strptime(mTime,format))+offset)
    # change timestamp of file
    fh = CreateFile(pathname, GENERIC_READ | GENERIC_WRITE, 0, None, OPEN_EXISTING, 0, 0) 
    createTime, accessTime, modifyTime = GetFileTime(fh)
    #print "Change Create from",createTime,"to %s" % (time.strftime(format,cTime_t))   
    #print "Change Access from",accessTime,"to %s" % (time.strftime(format,aTime_t))
    #print "Change Modify from",modifyTime,"to %s" % (time.strftime(format,mTime_t))
    #print ""
    createTime = Time(time.mktime(cTime_t))
    accessTime = Time(time.mktime(aTime_t))
    modifyTime = Time(time.mktime(mTime_t))
    SetFileTime(fh, createTime, accessTime, modifyTime)

    # check if all was ok
    #ctime = time.strftime(format,time.localtime(os.path.getctime(pathname)))
    #mtime = time.strftime(format,time.localtime(os.path.getmtime(pathname)))
    #atime = time.strftime(format,time.localtime(os.path.getatime(pathname)))
    #print "Create:%s,Access:%s,Modify:%s" %(ctime,atime,mtime)
    CloseHandle(fh)

base_dir = 'C:/Users/Administrator/Desktop/表格'
base_dir = unicode(base_dir, "utf8")

for path, dirs, files in os.walk(base_dir):
  for filename in files:    
    changeTime(path, filename)